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CBS polyclonal antibody

货号: BS6545

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS6545

Product Name :CBS polyclonal antibody

Swiss-Prot :P35520

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB, IF/ICC

Application_all :WB,1:500 - 1:1000|IF/ICC,1:50 - 1:200

Background :The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. This gene is a major contributor to cellular hydrogen sulfide production. Multiple alternatively spliced transcript variants have been found for this gene.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CBS polyclonal antibody detects endogenous levels of CBS protein.

BiowMW :61KDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :CBS;HIP4

Immunogen :Recombinant fusion protein of human CBS(NP_000062.1).

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of CBS expression in Hela (A), MCF7 (B), Romas (C), mouse brain (D) whole cell lysates.

Immunofluorescent analysis of CBS staining in U2OS cells.

Hydrogen sulfide inhibited L-type calcium channels (CaV1.2) via up-regulation of the channel sulfhydration in vascular smooth muscle cells

JournalEuropean Journal Of Pharmacology

ApplicationWB

IF3.17

SpeciesHuman

PMID31202801