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Bim polyclonal antibody

货号: BS6459

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS6459

Product Name :Bim polyclonal antibody

Swiss-Prot :O43521

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB, IHC, IF/ICC

Application_all :WB,1:500 - 1:1000|IHC,1:50 - 1:100|IF/ICC,1:50 - 1:200

Background :The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Bim polyclonal antibody detects endogenous levels of Bim protein.

BiowMW :~ 17 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :BAM;BIM;BOD;Bim;BCL2L11

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human BIM.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of BIM expression in HCT116 (A), HEK293T (B), SHSY5Y (C) whole cell lysates.

Immunohistochemical analysis of BIM staining in human breast cancer formalin fixed paraffin embedded tissue section.

Immunofluorescent analysis of BIM staining in VB2 cells.

BIMEL-mediated apoptosis in cumulus cells contributes to degenerative changes in aged porcine oocytes via a paracrine action

JournalTheriogenology

ApplicationWB,IF

IF2.299

SpeciesHuman

PMID21835451
GPER promotes tamoxifen-resistance in ER+ breast cancer cells by reduced Bim proteins through MAPK/Erk-TRIM2 signaling axis

JournalInternational Journal Of Oncology

ApplicationIHC,WB

IF3.571

SpeciesHuman

PMID28902352
Role of the AMPK signaling pathway in early brain injury after subarachnoid hemorrhage in rats

JournalActa Neurochirurgica

ApplicationWB

IF1.817

SpeciesRat

PMID25697836
Two clinical drugs deubiquitinase inhibitor auranofin and aldehyde dehydrogenase inhibitor disulfiram trigger synergistic anti-tumor effects in vitro and in vivo

JournalOncotarget

ApplicationWB

IF0

SpeciesHuman

PMID26625200