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[KO Validated] IGF1R polyclonal antibody

货号: BS6458

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS6458

Product Name :[KO Validated] IGF1R polyclonal antibody

Swiss-Prot :P08069

Host :Rabbit

Reactivity :Human, Mouse, Rat, Bovine, Chicken, Zebrafish

Applications :WB

Application_all :WB,1:500 - 1:1000

Background :This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IGF1R polyclonal antibody detects endogenous levels of IGF1R protein.

BiowMW :~ 95 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD221

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human IGF1R.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of IGF1R expression in HEK293T (A), SP2/0 (B), NIH3T3 (C) whole cell lysates.

Local insulin-like growth factor-I of ventral prostate was upregulated during long-term castration and may function through the autocrine system

JournalProstate Cancer And Prostatic Diseases

ApplicationIF,IHC

IF4.311

SpeciesRat

PMID21403669