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CD95/FAS polyclonal antibody

货号: BS6430

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS6430

Product Name :CD95/FAS polyclonal antibody

Swiss-Prot :P25445

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:2000 IHC: 1:50~1:200

Background :Cytotoxic T lymphocyte (CTL)-mediated cytotoxicity constitutes an important component of specific effector mechanisms in immuno- surveillance against virus-infected or transformed cells. Two mechanisms appear to account for this activity, one of which is the perforin-based process. Independently, a FASbased mechanism involves the transducing molecule FAS (also designated APO-1) and its ligand (FAS-L). The human FAS protein is a cell surface glycoprotein that belongs to a family of receptors that includes CD40, nerve growth factor receptors and tumor necrosis factor receptors. The FAS antigen is expressed on a broad range of lymphoid cell lines, certain of which undergo apoptosis in response to treatment with antibody to FAS. These findings strongly imply that targeted cell death is potentially mediated by the intercellular interactions of FAS with its ligand or effectors, and that FAS may be critically involved in CTL-mediated cytotoxicity.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Fas polyclonal antibody detects endogenous levels of Fas protein.

BiowMW :~ 38 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Death Receptor Signaling,

Alternative Name :Tumor necrosis factor receptor superfamily member 6; Apo-1 antigen; Apoptosis-mediating; surface antigen FAS; FASLG receptor; CD95; FAS; APT1; FAS1; TNFRSF6

Immunogen :Recombinant full length Human CD95/FAS.

Conjugate :Unconjugated

Modification :Unmodification

WesternBlot (WB) analysis of Fas polyclonal antibody.

iTRAQ-based quantitative proteomic analysis of the anti-apoptotic effect of hyperin, which is mediated by Mcl-1 and Bid, in H2O2-injured EA.hy926 cells

JournalInternational Journal Of Molecular Medicine

ApplicationWB

IF3.098

SpeciesHuman

PMID26935776
Protective Efficacy of Vitamins C and E on p,p′-DDT-Induced Cytotoxicity via the ROS-Mediated Mitochondrial Pathway and NF-κB/FasL Pathway

JournalPLoS One

ApplicationWB

IF2.776

SpeciesHuman

PMID25464339
Fluoxetine induces lipid metabolism abnormalities by acting on the liver in patients and mice with depression

JournalActa Pharmacologica Sinica

ApplicationWB

IF5.064

SpeciesMouse

PMID30150788