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ESRα polyclonal antibody

货号: BS6424

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS6424

Product Name :ESRα polyclonal antibody

Swiss-Prot :P03372

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB

Application_all :WB,1:1000 - 1:4000

Background :This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Polyclonal Antibodies

BiowMW :66KDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :ESR1;ER;ESR;ESRA;ESTRR;Era;NR3A1;ER alpha

Immunogen :Recombinant fusion protein of human ESRα(NP_000116.2).

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of extracts of HeLa cells, using ESRα antibody at 1:500 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit .
Exposure time: 180s.

Mechanisms of Gefitinib-mediated reversal of tamoxifen resistance in MCF-7 breast cancer cells by inducing ERα re-expression

JournalScientific Reports

ApplicationWB

IF4.011

SpeciesHuman

PMID25644501
GalNAc-T4 putatively modulates the estrogen regulatory network through FOXA1 glycosylation in human breast cancer cells

JournalMolecular And Cellular Biochemistry

ApplicationWB

IF2.884

SpeciesHuman

PMID26541755
Role of metformin in inhibiting estrogen‑induced proliferation and regulating ERα and ERβ expression in human endometrial cancer cells

JournalOncology Letters

ApplicationWB

IF2.311

SpeciesHuman

PMID29085506