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APP polyclonal antibody

货号: BS6418

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS6418

Product Name :APP polyclonal antibody

Swiss-Prot :P05067

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :IF/ICC

Application_all :IF/ICC,1:50 - 1:200

Background :This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Polyclonal Antibodies

BiowMW :100-140KDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :AAA;ABETA;ABPP;AD1;APPI;CTFgamma;CVAP;PN-II;PN2;Amyloid beta A4;APP;Aβ42;preA4

Immunogen :A synthetic peptide of human APP(NP_000475.1).

Conjugate :Unconjugated

Modification :Unmodification

Immunofluorescence analysis of HeLa cells using APP antibody at dilution of 1:100. Blue: DAPI for nuclear staining.

Effect of Moxibustion on Behavioral Changes and Expression of APP and BACE1 in Hippocampus of SAMP8 Mice

JournalEvidence-based Complementary and Alternative Medicine

ApplicationIHC,WB

IF1.813

SpeciesMouse

PMID32855649
Microbiota-derived metabolite Indoles induced aryl hydrocarbon receptor activation and inhibited neuroinflammation in APP/PS1 mice

JournalBRAIN BEHAVIOR AND IMMUNITY

ApplicationWB

IF19.227

SpeciesMouse

PMID35961580