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Catenin-β (phospho-Y670) polyclonal antibody

货号: BS64160

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :BS64160

Product Name :Catenin-β (phospho-Y670) polyclonal antibody

Swiss-Prot :P35222

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :β-Catenin is a key downstream effector in the Wnt signaling pathway. It is implicated in two major biological processes in vertebrates: early embryonic development and tumorigenesis. CK1 phosphorylates β-catenin at Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3β. GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41. Mutations at these sites result in the stabilization of β-catenin protein levels and have been found in many tumor cell lines.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Catenin-β (phospho-Y670) polyclonal antibody detects endogenous levels of Catenin-β protein only when phosphorylated at Tyr670.

BiowMW :~ 85 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Hypoxia Signaling,Wntβ catenin signaling，Contribution of ECM and Cytoskeletal Factors to EMT,Contribution of Soluble Factors to EMT,hippo Signaling,Adherens Junction signaling,

Alternative Name :Catenin beta-1; Beta-catenin; CTNNB1; CTNNB; OK/SW-cl.35; PRO2286

Immunogen :Synthetic phosphopeptide derived from human CTNNB1 around the phosphorylation site of Tyrosine 670.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot (WB) analysis Catenin-β (phospho-Y670) polyclonal antibody at 1:500 dilution Lane1:L02 whole cell lysate(40ug) Lane2:HepG2 whole cell lysate(40ug) Lane3:AML-12 whole cell lysate(40ug) Lane4:PC12 whole cell lysate(40ug)