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Phospho-p38 MAPK-Y182 polyclonal antibody

货号: BS6382

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :BS6382

Product Name :Phospho-p38 MAPK-Y182 polyclonal antibody

Swiss-Prot :Q16539

Host :Rabbit

Reactivity :Human, Mouse, Rat, Dog, Zebrafish

Applications :WB IHC IF/ICC

Application_all :WB: 1:500~1:1000 IHC: 1:100~1:200 IF/ICC: 1:100~1:500

Background :The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Phospho-p38 MAPK-Y182 polyclonal antibody detects endogenous levels of p38 MAPK protein only when phosphorylated at Tyr182.

BiowMW :~ 43 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :CSBP; CSBP1; CSBP2; CSPB1; MXI2; SAPK2A; Mitogen-activated protein kinase 14; MAP kinase 14; MAPK 14; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAP kinase MXI2; MAX-interacting protein 2; Mitogen-activated protein kinase p38 alpha; MAP kinase p38 alpha; Stress-activated protein kinase 2a; SAPK2a

Immunogen :KLH-conjugated synthetic phosphopeptide corresponding to residues surrounding Y182 of human p38 MAPK protein.

Conjugate :Unconjugated

Modification :Phosphorylated

Western blot analysis of Phospho-p38 MAPK-Y182 expression in PC3 (A), MCF7 (B), Raw264.7 (C), mouse muscle (D), rat muscle (E) whole cell lysates.

Immunohistochemical analysis of Phospho-p38 MAPK-Y182 staining in human breast cancer formalin fixed paraffin embedded tissue section.

Immunofluorescent analysis of Phospho-p38 MAPK-Y182 staining in HepG2 cells.

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