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Phospho-eIF4EBP1-T70 polyclonal antibody

货号: BS6357

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :BS6357

Product Name :Phospho-eIF4EBP1-T70 polyclonal antibody

Swiss-Prot :Q13541

Host :Rabbit

Reactivity :Human, Mouse, Rat, Monkey

Applications :WB, IHC

Application_all :WB,1:500 - 1:1000|IHC,1:100 - 1:200

Background :This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Phospho-eIF4EBP1-T70 polyclonal antibody detects endogenous levels of eIF4EBP1 protein only when phosphorylated at Thr70.

BiowMW :~ 15 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I

Immunogen :KLH-conjugated synthetic phosphopeptide corresponding to residues surrounding T69 of human eIF4EBP1 protein.

Conjugate :Unconjugated

Modification :Phosphorylated

Western blot analysis of Phospho-eIF4EBP1-T70 expression in U2OS (A), DLD (B) whole cell lysates.

Immunohistochemical analysis of Phospho-eIF4EBP1-T70 staining in human breast cancer formalin fixed paraffin embedded tissue section.