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AMHR2 polyclonal antibody

货号: BS6322

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS6322

Product Name :AMHR2 polyclonal antibody

Swiss-Prot :Q16671

Host :Rabbit

Reactivity :Human

Applications :WB ELISA

Application_all :WB 1:500 - 1:2000 ELISA 1:5000 - 1:10000

Background :MISR II (anti-Muellerian hormone type-2 receptor, MIS type II receptor) is a 573 amino acid protein encoded by the human gene AMHR2. MISR II belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily and contains one protein kinase domain. Upon ligand binding, MISR II forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. These type II receptors phospho-rylate and activate type I receptors which autophosphorylate, then bind and activate Smad transcriptional regulators. MISR II also acts as a receptor for anti-Muellerian hormone. Defects in AMHR2 are the cause of persistent Muellerian duct syndrome type 2 (PMDS-2). PMDS-2 is a form of male pseudo-hermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males.

Product :0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :AMHR2 polyclonal antibody detects endogenous levels of AMHR2 protein.

BiowMW :~ 63 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :TGFβ Smad signaling,

Alternative Name :Anti-Muellerian hormone type-2 receptor; Anti-Muellerian hormone type II receptor; AMH type II receptor; MIS type II receptor; MISRII; MRII; AMHR2; AMHR; MISR2

Immunogen :KLH conjugated synthetic peptide derived from human MISRII/AMHR2: 21-120/573 <Extracellular>

Conjugate :Unconjugated

Modification :Unmodification

Anti- AMHR2 at 1:300 dilution.