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eIF4EBP1 polyclonal antibody

货号: BS6290

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS6290

Product Name :eIF4EBP1 polyclonal antibody

Swiss-Prot :Q13541

Host :Rabbit

Reactivity :Human, Mouse, Rat, Bovine, Pig, Zebrafish

Applications :WB, IHC, IF/ICC

Application_all :WB,1:500 - 1:1000|IHC,1:100 - 1:200|IF/ICC,1:100 - 1:500

Background :This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :eIF4EBP1 polyclonal antibody detects endogenous levels of eIF4EBP1 protein.

BiowMW :~ 15 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human eIF4EBP1.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of eIF4EBP1 expression in HEK293T (A) whole cell lysates.

Immunohistochemical analysis of eIF4EBP1 staining in human lung cancer formalin fixed paraffin embedded tissue section.

Immunofluorescent analysis of eIF4EBP1 staining in MCF7 cells.

Apoptosis Induction by Iron Radiation via Inhibition of Autophagy in Trp53+/-Mouse Testes: Is Chronic Restraint-Induced Stress a Modifying Factor?

JournalInternational Journal of Biological Sciences

ApplicationWB

IF4.067

SpeciesMouse

PMID29989073