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PHD2/EGLN1 polyclonal antibody

货号: BS6184

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS6184

Product Name :PHD2/EGLN1 polyclonal antibody

Swiss-Prot :Q9GZT9

Host :Rabbit

Reactivity :Human

Applications :IF/ICC

Application_all :IF/ICC,1:50 - 1:200

Background :The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3).

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Polyclonal Antibodies

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :EGLN1;C1orf12;ECYT3;HALAH;HIF-PH2;HIFPH2;HPH-2;HPH2;PHD2;SM20;ZMYND6

Immunogen :Recombinant fusion protein of human PHD2/EGLN1(NP_071334.1).

Conjugate :Unconjugated

Modification :Unmodification

Immunofluorescence analysis of MCF-7 cells using PHD2/EGLN1 antibody . Blue: DAPI for nuclear staining.

Localized Delivery of shRNA against PHD2 Protects the Heart from Acute Myocardial Infarction through Ultrasound-Targeted Cationic Microbubble Destruction

JournalTheranostics

ApplicationWB

IF8.063

SpeciesRat

PMID28042316
PRL-3 promotes gastric cancer migration and invasion through a NF-κB-HIF-1α-miR-210 axis

JournalJournal Of Molecular Medicine-Jmm

ApplicationWB

IF4.746

SpeciesHuman

PMID26548949
Prolyl hydroxylase-2 inhibits liver tumor cell proliferation and cyclin D1 expression in a hydroxylase-dependent manner

JournalInternational Journal Of Biochemistry & Cell Biology

ApplicationIHC

IF3.673

SpeciesHuman

PMID27307407
Ultrasound-Targeted Microbubble Destruction (UTMD) Assisted Delivery of shRNA against PHD2 into H9C2 Cells

JournalPLoS One

ApplicationWB

IF2.776

SpeciesRat

PMID26267649