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Caveolin-2 polyclonal antibody

货号: BS61671

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :BS61671

Product Name :Caveolin-2 polyclonal antibody

Swiss-Prot :P51636

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :The 21-24 kDa integral proteins, caveolins, are the principal structural components of the cholesterol/sphingolipid-enriched plasma membrane microdomain caveolae. Three members of the caveolin family (caveolin-1, -2, and -3) have been identified with different tissue distributions. Caveolins form hetero- and homo-oligomers that interact with cholesterol and other lipids. Caveolins are involved in diverse biological functions, including vesicular trafficking, cholesterol homeostasis, cell adhesion, and apoptosis, and are also implicated in neurodegenerative disease. Caveolins interact with multiple signaling molecules such as Gα subunit, tyrosine kinase receptors, PKCs, Src family tyrosine kinases, and eNOS. It is believed that caveolins serve as scaffolding proteins for the integration of signal transduction. Phosphorylation at Tyr14 is essential for caveolin association with SH2 or PTB domain-containing adaptor proteins such as GRB7. Phosphorylation at Ser80 regulates caveolin binding to the ER membrane and entry into the secretory pathway.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CAV2 polyclonal antibody detects endogenous levels of CAV2 protein.

BiowMW :~ 18 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :ErbB HER Signaling,

Alternative Name :Caveolin2; CAV2; Caveolin 2

Immunogen :Synthetic peptide, corresponding Human CAV2.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of CAV2 polyclonal antibody at 1:500 dilution Lane1:CT26 whole cell lysate(40ug) Lane2:The Kidney tissue lysate of Rat(40ug) Lane3:A549 whole cell lysate(40ug) Lane4:COS-7 whole cell lysate(40ug) Lane5:Hela whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of Caveolin-2 polyclonal antibody in paraffin-embedded human kidney cancer tissue at 1:50.