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GUSB polyclonal antibody

货号: BS61590

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS61590

Product Name :GUSB polyclonal antibody

Swiss-Prot :P08236

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :The enzyme β-glucuronidase catalyzes the conversion of β-D-glucuronoside and water to an alcohol and D-glucuronate. Deficiency of β-glucuronidase is the cause of the human lysosomal storage disorder mucopolysaccharidosis type VII (MPS VII). Specifically, two residues appear important for catalytic activity: Glu 451 and Glu 540. Mutations at these sites affect the overall structure of the protein, which normally consists of a homotetramer with each promoter including a jelly roll barrel, an immunoglobulin constant domain and a TIM barrel. Regulation of β-glucuronidase activity may play a role in tumorigenesis and the invasiveness of a number of cancers, and is also an important factor in the development of functional prodrugs that require the cleavage of an active cytostatic by endogenous enzymes for antitumor activity.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 96% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :GUSB polyclonal antibody detects endogenous levels of GUSB protein.

BiowMW :~ 74 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :asd; Beta G1; Beta glucuronidase; Beta-G1; Beta-glucuronidase; BG; BGLR; BGLR_HUMAN; FLJ39445; Glucuronidase beta; Gur; Gus; Gus-r; Gus-s; Gus-t; Gus-u; GUSB; Gut; MPS7

Immunogen :Synthetic peptide, corresponding to amino acids 324-368 of Human GUSB.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of GUSB polyclonal antibody at 1:500 dilution Lane1:HepG2 whole cell lysate(40ug) Lane2:The liver tissue lysate of Fetal Mouse(40ug) Lane3:The lliver tissue lysate of Fetal Rat(40ug)