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AXL polyclonal antibody

货号: BS61370

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS61370

Product Name :AXL polyclonal antibody

Swiss-Prot :P30530

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB, IHC

Application_all :WB,1:500 - 1:2000|IHC,1:50 - 1:200

Background :Axl, Sky, and Mer are three members of a receptor tyrosine kinase (RTK) family that share a conserved intracellular tyrosine kinase domain and an extracellular domain similar to those seen in cell adhesion molecules. These RTKs bind the vitamin K-dependent protein growth-arrest-specific 6 (Gas6), which is structurally related to the protein S anticoagulation factor. Upon binding to its receptor, Gas6 activates phosphatidylinositol 3-kinase (PI3K) and its downstream targets Akt and S6K, as well as NF-κB. A large body of evidence supports a role for Gas6/Axl signaling in cell growth and survival in normal and cancer cells.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :AXL polyclonal antibody detects endogenous levels of AXL protein.

BiowMW :~ 110 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Tyrosine-protein kinase receptor UFO; AXL oncogene; AXL; UFO

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human AXL.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of AXL expression in PC3 (A), HEK293T (B), U87MG (C), SKOVCAR3 (D), C6 (E), CT26 (F) whole cell lysates.

Immunohistochemical analysis of AXL staining in human breast cancer formalin fixed paraffin embedded tissue section.

免疫沉淀（IP）

免疫组织化学（IHC）