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FAM3B polyclonal antibody

货号: BS6136

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS6136

Product Name :FAM3B polyclonal antibody

Swiss-Prot :P58499

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :IHC, IF/ICC

Application_all :IHC,1:100 - 1:200|IF/ICC,1:100 - 1:200

Background :FAM3B, also known as Pancreatic-derived factor (PANDER), is an islet-specific secreted cytokine specifically expressed at high levels in the islets of Langerhans of the endocrine pancreas. FAM3B can induce apoptosis of alpha and beta cells in a dose- and time-dependent manner. Previous studies showed that FAM3B regulates glucose and lipid metabolism through interaction with liver and endocrine pancreas. FAM3B silencing activates both extrinsic and intrinsic apoptotic pathways. In general, silencing FAM3B promoted p53 phosphorylation and induced p53 accumulation by decreasing Mdm2 expression, which resulted in apoptotic cell death.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Polyclonal Antibodies

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :FAM3B;2-21;C21orf11;C21orf76;ORF9;PANDER;PRED44

Immunogen :Recombinant fusion protein of human FAM3B(NP_478066.3).

Conjugate :Unconjugated

Modification :Unmodification

Immunohistochemistry of paraffin-embedded human colon using FAM3B antibody at dilution of 1:100 .Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.

Immunohistochemistry of paraffin-embedded human colon carcinoma using FAM3B antibody at dilution of 1:100 .Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.

Immunohistochemistry of paraffin-embedded human stomach using FAM3B antibody at dilution of 1:100 .Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.

Immunofluorescence analysis of mouse pancreas cells using FAM3B antibody at dilution of 1:100. Blue: DAPI for nuclear staining.