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ARSB polyclonal antibody

货号: BS60835

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS60835

Product Name :ARSB polyclonal antibody

Swiss-Prot :P15848

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:206

Background :Arylsulfatase B, also known as ARSB, ASB, MPS6 or G4S, is a 533 amino acid lysosomal protein that belongs to the sulfatase family. Existing as both a monomer and a homodimer, Arylsulfatase B uses calcium as a cofactor to hydrolyze C4-sulfate groups of N-Acetyl-D-galactosamine, dermatan sulfate and chondriotin sulfate, thereby playing a role in lysosomal degradation. Defects in the gene encoding Arylsulfatase B are the cause of mucopolysaccharidosis type 6 (MPS6) and multiple sulfatase deficiency (MSD), the first of which is a lysosomal storage disease that is characterized by short stature, stiff joints, skeletal malformations, corneal clouding, hepatosplenomegaly and cardiac abnormalities. In contrast, MSD is characterized by a decreased activity of all known sulfatases and is usually associated with mucopolysaccharidosis, chondrodysplasia punctata, hydrocephalus, ichthyosis and neurologic deterioration. Multiple isoforms of Arylsulfatase B exist due to alternative splicing events.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 101% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -26°C long term. Avoid freeze-thaw cycles.

Specificity :ARSB polyclonal antibody detects endogenous levels of ARSB protein.

BiowMW :~ 46 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Arylsulfatase B; ASB; N-acetylgalactosamine-4-sulfatase; G4S; ARSB

Immunogen :A synthetic peptide corresponding to residues in Human ARSB.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of ARSB polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:sp2/0 whole cell lysate Lane3:H9C8 whole cell lysate