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CARD14 polyclonal antibody

货号: BS60815

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS60815

Product Name :CARD14 polyclonal antibody

Swiss-Prot :Q9BXL6

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Membrane-associated guanylate kinase (MAGUK) family members localize to the plasma membrane and function as molecular scaffolds for the assembly of multi-protein complexes. The MAGUK family includes several mammalian proteins related to the Drosophila tumor suppressor discs-large (dlg) gene product, such as postsynaptic proteins, GKAPs, the tight junction associated proteins (ZO-1–3) and the caspase-associated recruitment domain (CARD) proteins: CARD 6, CARD 8-12 and CARD 14. CARD 14 is a 1,004 amino acid protein consisting of an N-terminal CARD domain, a central coiled-coil domain and a C-terminal tripartite domain comprised of a PDZ domain, an Src homology 3 domain and a GUK domain with homology to guanylate kinase. CARD 14 is expressed in the placenta where it positively regulates apoptosis. CARD 14 also controls NF˚B activation by phosphorylating BCL10, a signaling protein that activates NF˚B through the I˚B kinase complex. Epigallocatechin-3-gallate (EGCG) is a polyphenol that induces the expression of CARD 14.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CARD14 polyclonal antibody detects endogenous levels of CARD14 protein.

BiowMW :~ 113 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Caspase recruitment domain-containing protein 14; CARD-containing MAGUK protein 2; Carma 2; CARD14; CARMA2

Immunogen :A synthetic peptide corresponding to residues in Human CARD14.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of CARD14 polyclonal antibody at 1:500 dilution Lane1:A549 whole cell lysate Lane2:sp2/0 whole cell lysate Lane3:PC12 whole cell lysate