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TRAF6 polyclonal antibody

货号: BS6076

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS6076

Product Name :TRAF6 polyclonal antibody

Swiss-Prot :Q9Y4K3

Host :Rabbit

Reactivity :Human

Applications :IF/ICC

Application_all :IF/ICC,1:50 - 1:200

Background :The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Polyclonal Antibodies

BiowMW :Refer to figures

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :TRAF6;MGC:3310;RNF85

Immunogen :Recombinant fusion protein of human TRAF6(NP_004611.1).

Conjugate :Unconjugated

Modification :Unmodification

Immunofluorescence analysis of HeLa cells using TRAF6 Rabbit pAb at dilution of 1:100 . Blue: DAPI for nuclear staining.

Immunofluorescence analysis of NIH/3T3 cells using TRAF6 Rabbit pAb at dilution of 1:100 . Blue: DAPI for nuclear staining.

Immunofluorescence analysis of PC-12 cells using TRAF6 Rabbit pAb at dilution of 1:100 . Blue: DAPI for nuclear staining.

Neuroprotective effect of early and short-time applying sophoridine in pMCAO rat brain: Down-regulated TRAF6 and up-regulated p-ERK1/2 expression, ameliorated brain infaction and edema

JournalBrain Research Bulletin

ApplicationWB

IF4.077

SpeciesRat

PMID
Protosappanin A inhibits oxidative and nitrative stress via interfering the interaction of transmembrane protein CD14 with Toll-like receptor-4 in lipopolysaccharide-induced BV-2 microglia

JournalInternational Immunopharmacology

ApplicationWB

IF3.361

SpeciesMouse

PMID
Neuroprotective effect of bicyclol in rat ischemic stroke: Down-regulates TLR4, TLR9, TRAF6, NF-κB, MMP-9 and up-regulates claudin-5 expression

JournalBrain Research

ApplicationWB

IF3.252

SpeciesRat

PMID23850770
Mechanisms of CpG-induced CD40 expression on murine bone marrow-derived dendritic cells

JournalAutoimmunity

ApplicationWB

IF2.125

SpeciesMouse

PMID23244216
Cinnamaldehyde inhibits inflammation and brain damage in a mouse model of permanent cerebral ischaemia

JournalBritish Journal Of Pharmacology

ApplicationIHC,WB

IF8.739

SpeciesMouse

PMID