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CD3G polyclonal antibody

货号: BS60356

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS60356

Product Name :CD3G polyclonal antibody

Swiss-Prot :P09693

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :The T cell antigen receptor (TCR) recognizesforeign antigens and translates such recognition eventsinto intracellularsignalsthat elicit a change in the cell froma dormant to an activated state.Much of this signaling processcan be attributed to a multisubunitcomplex of proteins that associates directly with the TCR. Thiscomplex has been designated CD3 (cluster of differentiation 3). It iscomposed of five invariant polypeptide chainsthat associate to form three dimers: a heterodimer of γ and ε chains(γε), a heterodimer of δ and ε chains(δε) and a homodimer of two ζ chains(ζζ) or a heterodimer of ζ and η chains(ζη). The ζ and η chains are encoded bythe same gene but differ in theircarboxyl-terminal ends due to an alternative splicing event. The γ, ε and δ chains each contain a single copy of a conserved immunoreceptor tyrosine-based activationmotif (ITAM). In contrast, the ζ chain containsthree consecutive copies of the same motif. Phosphorylated ITAMs act as docking sitesfor protein kinases such as ZAP-70 and Syk and are also capable of regulating theirkinase activity. The crystalstructure of ZAP-70’s SH2 domains bound to the ζ chain ITAMs has been solved.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CD3G polyclonal antibody detects endogenous levels of CD3G protein.

BiowMW :~ 20 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :T-cell surface glycoprotein CD3 gamma chain; T-cell receptor T3 gamma chain; CD3g; CD3G; T3G; CD3-γ; CD3 γ; CD3γ

Immunogen :A synthetic peptide corresponding to residues in Human CD3G.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of CD3G polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:H9C2 whole cell lysate