Product Name :CACNA1E polyclonal antibody
Reactivity :Human,Mouse,Rat
Application_all :WB: 1:500~1:1000
Background :Voltage-dependent Ca2+ channelsmediate Ca2+ entryinto excitable cells in response tomembrane depolarization, and they are involved in a variety of Ca2+-dependent processes, includingmuscle contraction, hormone or neurotransmitter release and gene expression. Calciumchannels are highly diverse, multimeric complexescomposed of anα-1 subunit, an intracellular β-subunit, a disulfide linkedα-2/δ-subunit and a transmembrane γ-subunit. Ca2+ currents are characterized on the basis of their biophysical and pharmacologic properties and include L-, N-, T-, P-, Q-, and R-types. R-type Ca++ currentsinitiate a rapid synaptictransmission that isregulated through G proteins, SNARE proteins, and protein phosphorylation. R-type Ca++ channels may partially regulate the secretory processin chromaffin cells bymediating rapid secretoryresponses evoked byshort depolarizing pulses.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :CACNA1E polyclonal antibody detects endogenous levels of CACNA1E protein.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :Voltage-dependent R-type calcium channel subunit alpha-1E; Brain calcium channel II; BII; Calcium channel, L type, alpha-1 polypeptide, isoform 6; Voltage-gated calcium channel subunit alpha Cav2.3; CACNA1E; CACH6, CACNL1A6
Immunogen :A synthetic peptide corresponding to residues in Human CACNA1E.
Modification :Unmodification
