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AXIN1 polyclonal antibody

货号: BS60118

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS60118

Product Name :AXIN1 polyclonal antibody

Swiss-Prot :O15169

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :β-catenin is a component of both the cadherin cell adhesion system and the Wnt signaling pathway. Wnt signaling increases the amount of β-catenin by preventing its ubiquitination and degradation, allowing its direct interaction with transcription factors of the lymphoid enhancer factor/T cell factor family, and modulation of gene expression. Axin is involved in the degradation of β-catenin by acting as a scaffold to form a complex between β-catenin, adenomatous polyposis coli (APC) and GSK-3β. APC, which is phosphorylated by GSK-3β, induces degradation of β-catenin, thus inhibiting Wnt signal transduction. Conductin is 45% identical to Axin and appears to play a similar role to Axin in the Wnt signaling pathway.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :AXIN1 polyclonal antibody detects endogenous levels of AXIN1 protein.

BiowMW :~ 110 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Wntβ catenin signaling，Contribution of Soluble Factors to EMT,

Alternative Name :Axin-1; Axis inhibition protein 1; hAxin; AXIN1; AXIN

Immunogen :A synthetic peptide corresponding to residues in Human AXIN1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of AXIN1 polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:NIH-3T3 whole cell lysate Lane3:PC12 whole cell lysate