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Ataxin-10 polyclonal antibody

货号: BS60104

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS60104

Product Name :Ataxin-10 polyclonal antibody

Swiss-Prot :Q9UBB4

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Spinocerebellar ataxia (SCA) is an autosomal dominant neurodegenerative disorder characterized by ataxia and selective neuronal cell loss. SCA is caused by the expansion of a translated CAG repeat, encoding a polyglutamine tract in SCA gene products, known as ataxins. The ataxin proteins are ubiquitously expressed in nervous tissue, but are primarily detected in cerebellum, brain stem and spinal cord in the central nervous system. Ataxin-10 is a cytoplasmic protein that belongs to the family of armadillo repeat proteins. A loss of ataxin-10 in primary neuronal cells causes increased apoptosis of cerebellar neurons. Ataxin-10 interacts with p110, an O-Linked beta-N-acetylglucosamine transferase, and may be important in the regulation of intracellular glycosylation levels and homeostasis in the brain. Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant disorder that causes cerebellar ataxia and seizures. SCA10 is caused by an expansion of an ATTCT pentanucleotide repeat in intron 9 of the ataxin-10 gene.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Ataxin-10 polyclonal antibody detects endogenous levels of Ataxin-10 protein.

BiowMW :~ 46-53 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Ataxin 10; Ataxin10; Brain protein E46 homolog; Spinocerebellar ataxia type 10 protein; ATXN10; SCA10

Immunogen :A synthetic peptide corresponding to residues in Human Ataxin-10.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Ataxin-10 polyclonal antibody at 1:500 dilution Lane1:Hela whole cell lysate Lane2:sp2/0 whole cell lysate Lane3:H9C2 whole cell lysate