Product Name :CACNG1 polyclonal antibody
Reactivity :Human,Mouse,Rat
Application_all :WB: 1:500~1:1000
Background :Voltage-dependent calcium channels are essential for the release of neurotransmitters. L-type (long lasting current) voltage-dependent calcium channels are composed of four subunits: an α1 subunit, a β subunit, a γ subunit and an α2δ subunit. The β subunit is encoded by four genes, designated β1-β4, all of which contribute to the diversity of calcium currents and are involved in membrane trafficking of the α1 subunit. L-type Ca ++ CP γ1, also known as CACNLG or CACNG1, is a 222 amino acid multi-pass membrane protein belonging to the PMP-22/EMP/MP20 family. Expressed in skeletal muscle, L-type Ca ++ CP γ1 is a subunit of the dihydropyridine (DHP) sensitive calcium channel and may play a role in excitation-contraction coupling. L-type Ca++ CP γ1 is considered a novel marker for malignant hyperthermia susceptibility (MHS), an autosomal dominant disorder of skeletal muscle which manifests as a life-threatening hypermetabolic crisis triggered by commonly used inhalation anaesthetics and depolarizing muscle relaxants.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :CACNG1 polyclonal antibody detects endogenous levels of CACNG1 protein.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :Voltage-dependent calcium channel gamma-1 subunit; Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma; CACNLG; L-type Ca++ CP γ1; L-type Ca++ CPγ1
Immunogen :Synthetic peptide, corresponding to the 177-222 of Human CACNG1.
Modification :Unmodification
