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ATM (I1987) polyclonal antibody（KU）

货号: BS5505

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS5505

Product Name :ATM (I1987) polyclonal antibody（KU）

Swiss-Prot :Q13315

Host :Rabbit

Reactivity :Human

Applications :WB IHC

Application_all :IHC: 1:50~1:200

Background :The phosphatidylinositol kinase (PIK) family members fall into two distinct subgroups. The first subgroup contains proteins such as the PI 3- and PI 4-kinases and the second group comprises the PIK-related kinases. The PIK-related kinases include Atm, DNA-PKCS and FRAP. These proteins have in common a region of homology at their carboxy-termini that is not present in the PI 3- and PI 4-kinases. The Atm gene is mutated in the autosomal recessive disorder ataxia telangiectasia (AT) that is characterized by cerebellar degeneration (ataxia) and the appearance of dilated blood vessels (telangiec-tases) in the conjunctivae of the eyes. AT cells are hypersensitive to ionizing radiation, impaired in mediating the inhibition of DNA synthesis and display delays in p53 induction.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :ATM (I1987) polyclonal antibody detects endogenous levels of ATM protein.

BiowMW :~ 350 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Cell Cycle Control G1 S Checkpoint,Cell Cycle G2 M DNA Damage Signaling Pathway,Mitochondrial Control of Apoptosis,

Alternative Name :A-T mutated; A-T mutated homolog; AT complementation group A; AT complementation group C; AT complementation group D; AT complementation group E; AT mutated; AT protein; AT1; AT1; ATA; Ataxia telangiectasia gene mutated in human beings; Ataxia telangiectasia mutated; Ataxia telangiectasia mutated gene; Ataxia telangiectasia mutated homolog (human); Ataxia telangiectasia mutated homolog; ATC; ATD; ATDC; ATE; ATM; ATM; DKFZp781A0353; Human phosphatidylinositol 3 kinase homolog; MGC74674; OTT

Immunogen :Synthetic peptide, corresponding to amino acids 1957-2006 of Human ATM.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of ATM (I1987) pAb at 1:500 dilution Lane1:HEK293T whole cell lysate(40ug) Lane2:L02 whole cell lysate(40ug) Lane3:H1792 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of ATM (I1987) pAb in paraffin-embedded human liver carcinoma tissue at 1:100.

Roles of Kruppel-associated Box (KRAB)-associated Co-repressor KAP1 Ser-473 Phosphorylation in DNA Damage Response

JournalJournal Of Biological Chemistry

ApplicationIF

IF4.238

SpeciesHuman

PMID22496453