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BRCC36 Recombinant Rabbit mAb (KU)

货号: BS47794

价格：￥ 1200

货期：现货（1-2个工作日）

25ul 50ul 100ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS47794

Product Name :BRCC36 Recombinant Rabbit mAb (KU)

Swiss-Prot :P46736

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB,ICC/IF,IP

Application_all :WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/20

Background :This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011]

Product :Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :Calculated MW: 124 kDa; Observed MW: 124 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :VCL; Vinculin; Metavinculin

Immunogen :A synthesized peptide derived from human Vinculin

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of Vinculin in Jurkat, COS7, HepG2, U2OS, Hela lysates using Vinculin antibody.

免疫沉淀（IP）