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PMS2 Recombinant Rabbit mAb (KU)

货号: BS47308

价格：￥ 1200

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS47308

Product Name :PMS2 Recombinant Rabbit mAb (KU)

Swiss-Prot :P54278

Host :Rabbit

Reactivity :Human

Applications :WB, IHC, ICC/IF, FC, IP

Application_all :WB: 1:2000<br />IHC: 1:50<br />ICC/IF: 1:50<br />FC: 1:100<br />IP: 1:20

Background :The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome. [provided by RefSeq, Apr 2016]

Product :Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Purification&Purity :Affinity Purification

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :96 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :MLH4; PMSL2; HNPCC4; PMS2CL

Immunogen :A synthetic peptide of human PMS2

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of PMS2 in Jurkat,Hela cell lysates using PMS2 antibody(1:1000 diluted).

免疫沉淀（IP）

免疫组织化学（IHC）