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KCTD21 Recombinant Rabbit mAb (KU)

货号: BS46925

价格：￥ 1200

货期：现货（1-2个工作日）

25ul 50ul 100ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS46925

Product Name :KCTD21 Recombinant Rabbit mAb (KU)

Swiss-Prot :Q4G0X4

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB,FC

Application_all :WB,1:500 - 1:2000|FC,1:50 - 1:200

Background :Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142).

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Polyclonal Antibodies

BiowMW :66KDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :GPC3;DGSX;GTR2-2;MXR7;OCI-5;SDYS;SGB;SGBS;SGBS1;glypican-3

Immunogen :A synthetic peptide of human Glypican 3 (GPC3)(NP_004475.1).

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of extracts of various cell lines, using Glypican 3 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit .
Exposure time: 180s.