Product Name :HIF-1-alpha Recombinant Rabbit mAb (KU)
Reactivity :Human, Mouse, Rat
Application_all :WB: 1/500-1/1000 IF: 1/50-1/200
Background :This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011]
Product :Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Purification&Purity :Affinity Purified
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
BiowMW :Calculated MW: 15 kDa; Observed MW: 15 kDa
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :H3 histone; family 3A; H3 histone; family 3B (H3.3B); H3.3A; H3.3B; H33; H3F3; H3F3A; H3F3B; Histone H3.3
Immunogen :Human Phospho-Histone H3(Ser10) synthetic peptide conjugated to KLH.
Modification :Phosphorylated
