Product Name :P300/CBP Recombinant Rabbit mAb (KU)
Reactivity :Human, Mouse, Rat
Applications :WB,ICC/IF,FC,IP
Application_all :WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/20 FC: 1/50-1/100
Background :This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]
Product :50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Purification&Purity :Affinity Purified
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
BiowMW :Calculated MW: 44 kDa; Observed MW: 44 kDa
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :APOL1; APOL; Apolipoprotein L1; Apolipoprotein L; Apo-L; ApoL; Apolipoprotein L-I; ApoL-I
Immunogen :A synthetic peptide of human Apolipoprotein L 1
