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Angiotensin II Type 2 Receptor Recombinant Rabbit mAb (KU)

货号: BS45896

价格：￥ 1200

货期：现货（1-2个工作日）

25ul 50ul 100ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS45896

Product Name :Angiotensin II Type 2 Receptor Recombinant Rabbit mAb (KU)

Swiss-Prot :P50052

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB,IP

Application_all :WB,1:500 - 1:2000|IP,1:50 - 1:200

Background :The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked cognitive disability. Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and SARS-CoV-2 infection result in down-regulation of ACE2 (angiotensin converting enzyme-2) receptors which triggers serious inflammatory lesions, primarily in the lungs. The inflammatory reaction is mediated by angiotensin II derivatives; however, while the ACE2-angiotensin II-angiotensin AT1 receptor pathway contributes to the pathophysiology of ARDS (acute respiratory distress syndrome), the activation of the ACE-2-angiotensin(1-7)-angiotensin AT2 receptor and the ACE-2-angiotensin(1-7)-Mas receptor pathways have been shown to be protective. [provided by RefSeq, Jun 2020]

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Polyclonal Antibodies

BiowMW :108kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :NLRX1;CLR11.3;DLNB26;NOD26;NOD5;NOD9

Immunogen :Recombinant fusion protein of human NLRX1(NP_001269073.1).

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of extracts of various cell lines, using NLRX1 antibody at 1:3000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit .
Exposure time: 10s.