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CDKN2A/p16INK4a Recombinant Rabbit mAb (KU)

货号: BS45515

价格：￥ 1200

货期：现货（1-2个工作日）

25ul 50ul 100ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS45515

Product Name :CDKN2A/p16INK4a Recombinant Rabbit mAb (KU)

Swiss-Prot :P42771

Host :Rabbit

Reactivity :Human

Applications :WB,ICC/IF,FC

Application_all :WB: 1/500-1/1000 IF: 1/50-1/200 FC: 1/50-1/100

Background :This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]

Product :Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :Calculated MW: 45 kDa; Observed MW: 45 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :PGKA; MIG10; HEL-S-68p

Immunogen :A synthesized peptide derived from human PGK1

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of PGK1 in HepG2 lysates; mouse kidney lysates using PGK1 antibody.

Western blot analysis of PGK1 in SKOV-3, Jurkat, U251, PC-3 and Hela lysates using PGK1 antibody.