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Catenin-δ1 (phospho-Y228) polyclonal antibody（KU）

货号: BS4381

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS4381

Product Name :Catenin-δ1 (phospho-Y228) polyclonal antibody（KU）

Swiss-Prot :O60716

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Catenin δ-1 (p120 catenin) has an amino-terminal coiled-coil domain followed by a regulatory domain containing multiple phosphorylation sites and a central Armadillo repeat domain of ten linked 42-amino acid repeats. The carboxy-terminal tail has no known function. Catenin δ-1 fulfills critical roles in the regulation of cell-cell adhesion as it regulates E-cadherin turnover at the cell surface to determine the level of E-cadherin available for cell-cell adhesion. Catenin δ-1 has both positive and negative effects on cadherin-mediated adhesion. Actin dynamics are also regulated by catenin δ-1, which modulates RhoA, Rac, and cdc42 proteins. Analogous to β-catenin, catenin δ-1 translocates to the nucleus, although its role at this location is unclear. Many studies show that catenin δ-1 is expressed irregularly or is absent in various types of tumor cells, suggesting that catenin δ-1 may function as a tumor suppressor.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Catenin-δ1 (phospho-Y228) polyclonal antibody detects endogenous levels of Catenin-δ1 protein only when phosphorylated at Tyr228.

BiowMW :~ 95, 100 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Contribution of ECM and Cytoskeletal Factors to EMT,

Alternative Name :Catenin delta-1; Cadherin-associated Src substrate; CAS; p120 catenin; p120(ctn); p120(cas); CTNND1

Immunogen :Synthetic phosphopeptide derived from human Catenin-δ1 around the phosphorylation site of Tyrosine 228

Conjugate :Unconjugated

Modification :Phosphorylated

Western blot (WB) analysis of Catenin-δ1 (phospho-Y228) polyclonal antibody at 1:500 dilution Lane1:Hela whole cell lysate(40µg) Lane2:K562 whole cell lysate(40µg) Lane3:RAW264.7 whole cell lysate(40µg) Lane4:C6 whole cell lysate(40µg)