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Phospho-PTP1B (Ser352) Recombinant Rabbit mAb (KU)

货号: BS43107

价格：￥ 1200

货期：现货（1-2个工作日）

25ul 50ul 100ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS43107

Product Name :Phospho-PTP1B (Ser352) Recombinant Rabbit mAb (KU)

Swiss-Prot :P18031

Host :Rabbit

Reactivity :Human

Applications :WB,ICC/IF,IP

Application_all :WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/20

Background :The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

Product :Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :Calculated MW: 124 kDa; Observed MW: 124 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :VCL; Vinculin; Metavinculin

Immunogen :A synthesized peptide derived from human Vinculin

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of Vinculin in Jurkat, COS7, HepG2, U2OS, Hela lysates using Vinculin antibody.

免疫沉淀（IP）