Product Name :Catenin-β (phospho-T41/S45) polyclonal antibody
Reactivity :Human,Mouse,Rat
Application_all :IHC: 1:50~1:200
Background :β-Catenin is a key downstream effector in the Wnt signaling pathway. It is implicated in two major biological processes in vertebrates: early embryonic development and tumorigenesis. CK1 phosphorylates β-catenin at Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3β. GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41. Mutations at these sites result in the stabilization of β-catenin protein levels and have been found in many tumor cell lines.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :p-Catenin-β (T41+S45) polyclonal antibody detects endogenous levels of Catenin-β protein only when phosphorylated at Thr41+S45 .
Note :For research use only, not for use in diagnostic procedure.
Pathway :Hypoxia Signaling,Wntβ catenin signaling，Contribution of ECM and Cytoskeletal Factors to EMT,Contribution of Soluble Factors to EMT,hippo Signaling,Adherens Junction signaling,
Alternative Name :Catenin β; Cateninβ; Catenin beta-1; Beta-catenin; CTNNB1; CTNNB; ORF Names: OK/SW-cl.35; PRO2286
Immunogen :A phospho specific peptide corresponding to residues surrounding threonine 41 and 45 of Human Catenin-β.
Modification :Phosphorylation
