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Cardiotrophin-1 (H31) polyclonal antibody（KU）

货号: BS3672

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS3672

Product Name :Cardiotrophin-1 (H31) polyclonal antibody（KU）

Swiss-Prot :Q16619

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :Cardiotrophin-1 (CT-1) is a member of the IL-6 family of cytokines, which signal through gp130 receptor complexes. gp130 complexes with several different receptor subunits to transmit signals from Cardiotrophin-1, IL-6, LIF, OSM, CNTF and IL-11. Cardiotrophin-1 binds to and activates the leukemia inhibitory factor (LIF) receptor/gp130 receptor complex and has been shown to induce hypertrophy in cardiac myocytes in vitro. Cardiotrophin-1, a secreted protein expressed at high levels in myocardium during cardiogenesis, has been shown to promote proliferation and survival of embryonic cardiomyocytes, suggesting a role for Cardiotrophin-1 in the activation of gp130 during cardiac development.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Cardiotrophin-1 (H31) polyclonal antibody detects endogenous levels of Cardiotrophin-1 protein.

BiowMW :~ 27 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Cardiotrophin-1; CT-1; CTF1; Cardiotrophin1; CT1; Cardiotrophin 1; CT 1;

Immunogen :Synthetic peptide, corresponding to amino acids 1-53 of Human CT-1.

Conjugate :Unconjugated

Modification :Unmodified

Western blot (WB) analysis of Cardiotrophin-1 (H31) pAb at 1:500 dilution Lane1:PC3 whole cell lysate(40ug) Lane2:K562 whole cell lysate(20ug) Lane3:Jurkat whole cell lysate(40ug) Lane4:The Muscle tissue lysate of Mouse(40ug) Lane5:H9C2 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of Cardiotrophin-1 (H31) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Cardiotrophin-1 (CTF1) ameliorates glucose-uptake defects and improves memory and learning deficits in a transgenic mouse model of Alzheimer's disease

JournalPharmacology Biochemistry And Behavior

ApplicationWB

IF2.519

SpeciesMouse

PMID23541490