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MyD88 (V220) polyclonal antibody

货号: BS3521

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS3521

Product Name :MyD88 (V220) polyclonal antibody

Swiss-Prot :Q99836

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :The myeloid differentiation protein MyD88 was originally characterized as a protein upregulated in myeloleukemic cells following IL-6-induced growth arrest and terminal differentiation. MyD88 is now known to function as an adaptor protein for the association of IRAK with the IL-1 receptor. MyD88 is functionally homologous to the adaptor protein tube in the Toll signaling pathway of Drosophilia, and both proteins are members of the Toll/IL-1R superfamily. MyD88 contains a characteristic N-terminal death domain that is essential for NFκB activation and an adjacent Toll/IL-1R homology domain (TIR domain). Collectively, these domains enable the protein-protein interactions of MyD88 with IRAK and the IL-1 receptor complex.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :MyD88 (V220) polyclonal antibody detects endogenous levels of MyD88 protein.

BiowMW :~ 35 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Toll-like Receptor signaling,

Alternative Name :Myeloid differentiation primary response protein MyD88

Immunogen :Synthetic peptide, corresponding to amino acids 186-236 of Human MyD88.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of MyD88 (V220) polyclonal antibody at 1:500 dilution Lane1:MCF-7 whole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:PC12 whole cell lysate

Immunohistochemistry (IHC) analyzes of MyD88 (V220) pAb in paraffin-embedded human brain tissue.

Suppressing TLR4 alleviates cerebral injury in heatstroke rats through the modulation of microglial polarization

JournalINTERNATIONAL JOURNAL OF HYPERTHERMIA

ApplicationWB

IF3

SpeciesRat

PMID40376840