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AR-β3 (L291) polyclonal antibody

货号: BS3158

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS3158

Product Name :AR-β3 (L291) polyclonal antibody

Swiss-Prot :P13945

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Beta 3-adrenergic receptors (b3-ARs) bind cathecholamines (epinephrine, norepinephrine), and primarily regulate lipolysis and thermogenesis in adipose. b3-ARs are present in adipose tissues, heart, and in smooth muscle of bladder, colon, small intestine, and stomach. The human corpus cavernosum exhibits basal b3-AR-mediated vasorelaxant tone and activity is linked to inhibition of the RhoA/Rho-kinase pathway. b3-AR interacts directly with the SH3 domain of Src through proline-rich motifs (PXXP) in the third intracellular loop and the carboxy-terminus.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :AR-β3 (L291) polyclonal antibody detects endogenous levels of AR-β3 protein.

BiowMW :~ 43, 68 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Beta-3 adrenergic receptor; Beta-3 adrenoreceptor; Beta-3 adrenoceptor; ADRB3; ADRB3R; B3AR; AR β3; ARβ3; β3-AR; β3 AR; β3AR

Immunogen :Synthetic peptide, corresponding to amino acids 250-300 of Human AR-β3.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of AR-β3 (L291) polyclonal antibody at 1:500 dilution Lane1:MCF-7 cell lysate Lane2:Mouse kidney tissue lysate Lane3:Rat liver tissue lysate

Butyrate stimulates adipose lipolysis and mitochondrial oxidative phosphorylation through histone hyperacetylation‐associated β3‐adrenergic receptor activation in high‐fat diet‐induced obese mice

JournalExperimental Physiology

ApplicationWB

IF2.431

SpeciesMouse

PMID28028849
Konjac glucomannan attenuate high-fat diet-fed obesity through enhancing β-adrenergic-mediated thermogenesis in inguinal white adipose tissue in mice

JournalGLYCOCONJUGATE JOURNAL

ApplicationWB

IF3

SpeciesMouse

PMID37535173