产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

CLN6 (N258) polyclonal antibody

货号: BS3102

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS3102

Product Name :CLN6 (N258) polyclonal antibody

Swiss-Prot :Q9NWW5

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :CLN6, a 311-amino acid protein, has 7 predicted transmembrane domains and is conserved across vertebrates. The CLN6 protein localizes to the endoplasmic reticulum but contributes to lysosomal function. Mutations in the CLN6 gene cause variant late-onset infantile neuronal ceroid lipofuscinosis (vLINCL), a lysosomal storage disorder marked by progressive mental deterioration and blindness; part of a group of severe inherited neurodegenerative disorders affecting children wherein lysosomes accumulate storage material, causing the death of neurons. CLN6 is one of eight proteins, including CLN1-8, that are associated with NCL.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CLN6 (N258) polyclonal antibody detects endogenous levels of CLN6 protein.

BiowMW :~ 40 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Ceroid-lipofuscinosis neuronal protein 6; Protein CLN6; CLN6

Immunogen :Synthetic peptide, corresponding to amino acids 229-274 of Human CLN6.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of CLN6 (N258) pAb at 1:500 dilution Lane1:SGC7901 whole cell lysate(40ug) Lane2:SK-OVCAR3 whole cell lysate(40ug) Lane3:MCF-7 whole cell lysate(40ug) Lane4:PC12 whole cell lysate(40ug) Lane5:CT26 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of CLN6 (N258) pAb in paraffin-embedded human stomach carcinoma tissue at 1:50.showing nuclear and strong cytoplasmic staining. Negative control (the right)Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.