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P-Cadherin (G78) polyclonal antibody（KU）

货号: BS2577

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS2577

Product Name :P-Cadherin (G78) polyclonal antibody（KU）

Swiss-Prot :P22223

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :The cadherins are a family of Ca++-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. Cadherins each contain a large extracellular domain at the amino terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short carboxy terminal, intracellular domain interacts with a variety of cytoplasmic proteins, including β-catenin, to regulate cadherin function. R-cadherin (for retinal-cadherin, also designated cadherin-4), which was first identified in the retina of chicken, has been shown to be involved in the development of striated muscle and potentially epithelia in addition to its involvement in retinal development.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :P-Cadherin (G78) polyclonal antibody detects endogenous levels of P-Cadherin protein.

BiowMW :~ 110 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Adherens Junction signaling,

Alternative Name :Placental cadherin; P-cadherin; CDH3; CDHP

Immunogen :Synthetic peptide, corresponding to amino acids 45-90 of Human P-Cadherin.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of P-cadherin (G78) pAb Antibody at 1:500 dilution Lane1:A375 whole cell lysate(40ug) Lane2:C6 whole cell lysate(40ug) Lane3:Beas-2B whole cell lysate(40ug) Lane4:EC9706 whole cell lysate(40ug) Lane5:CT26 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of P-cadherin (G78) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.