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ARHGEF2 (P881) polyclonal antibody（KU）

货号: BS2442

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS2442

Product Name :ARHGEF2 (P881) polyclonal antibody（KU）

Swiss-Prot :Q92974

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :GEFs catalyze the release of GDP from inactive Ras proteins to ena-ble GTP binding. Lfc (also designated Rho/Rac guanine nucleotide exchange factor 2, lymphoid blast crisis-like 1, ARHGEF2, GEF-H1, KIAA0651 or LFP40) is an 894 amino acid GEF for Rho A, a member of the Ras family that regulates the Actin cytoskeleton during the formation of stress fibers. Lfc directly interacts with Cingulin, a junctional adapter that inhibits Rho A, thus preventing phorbol-12-myristate-13-acetate-induced contraction and apoptosis. Mutations in the p53 gene transcriptionally activate Lfc, thereby increasing tumor cell proliferation.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :ARHGEF2 (P881) polyclonal antibody detects endogenous levels of ARHGEF2 protein.

BiowMW :~ 110 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Regulation of Actin Dynamics,Regulation of Microtubule Dynamics,

Alternative Name :Rho guanine nucleotide exchange factor 2; Guanine nucleotide exchange factor H1; GEF-H1; Microtubule-regulated Rho-GEF; Proliferating cell nucleolar antigen p40; ARHGEF2; KIAA0651; LFP40

Immunogen :Synthetic peptide, corresponding to amino acids 850-897 of Human ARHGEF2.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of ARHGEF2 (P881) pAb at 1:500 dilution Lane1:PMVEC whole cell lysate(40ug) Lane2:AML-12 whole cell lysate(40ug) Lane3:MCF-7 whole cell lysate(40ug) Lane4:A549 whole cell lysate(40ug) Lane5:HuT78 whole cell lysate(20ug)