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ATF3 (N159) polyclonal antibody（KU）

货号: BS2261

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS2261

Product Name :ATF3 (N159) polyclonal antibody（KU）

Swiss-Prot :P18847

Host :Rabbit

Reactivity :Human,Rat

Applications :WB IHC

Application_all :WB: 1:1000~1:2000 IHC: 1:50~1:200

Background :Activating transcription factor 3 is a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. It encodes a protein with a calculated molecular mass of 22 kD. ATF3 represses rather than activates transcription from promoters with ATF binding elements. An alternatively spliced form of ATF3 (ATF3 delta Zip) encodes a truncated form ATF3 protein lacking the leucine zipper protein-dimerization motif and does not bind to DNA. In contrast to ATF3, ATF3 delta Zip stimulates transcription presumably by sequestering inhibitory co-factors away from the promoter. It is possible that alternative splicing of the ATF3 gene may be physiologically important in the regulation of target genes. Three transcript variants encoding two different isoforms have been found for this gene.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :ATF-3 (N159) polyclonal antibody detects endogenous levels of ATF-3 protein.

BiowMW :~ 24 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Cyclic AMP-dependent transcription factor ATF-3; cAMP-dependent transcription factor ATF-3; Activating transcription factor 3; ATF3; ATF 3

Immunogen :Synthetic peptide, corresponding to Human ATF3.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of ATF3 (N159) pAb at 1:500 dilution Lane1:L02 whole cell lysate(40ug) Lane2:SGC7901 whole cell lysate(40ug) Lane3:A549 whole cell lysate(40ug) Lane4:HEK293T whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of ATF3 (N159) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Western blot (WB) analysis of ATF3 (N159) at 1:1000 dilution Lane1:The heart tissue lysate of Rat(30ug) Lane2:HepG2 whole cell lysate(30ug)

miRNA expression pattern associated with prognosis in elderly patients with advanced OPSC and OCC

JournalInternational Journal Of Oncology

ApplicationIHC

IF5.65

SpeciesHuamn

PMID23787480
KPNB1 inhibition disrupts proteostasis and triggers unfolded protein response-mediated apoptosis in glioblastoma cells

JournalOncogene

ApplicationWB

IF6.634

SpeciesHuman

PMID29520102