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CD83 (P130) polyclonal antibody

货号: BS2204

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS2204

Product Name :CD83 (P130) polyclonal antibody

Swiss-Prot :Q01151

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :CD83 is a heavily glycosylated membrane protein of the immunoglobulin (Ig) superfamily that is expressed in mature dendritic cells, Langerhans cells and interdigitating reticulum cells within lymphoid tissues. Structurally, CD83 resembles other Ig superfamily members, which have an extracellular V-type Ig-like domain, a single transmembrane domain and a 40 residue cytoplasmic tail. CD83 expression is used as a marker for mature, antigen presenting dendritic cells that are capable of generating tumor-specific T cell immunity, a phenotype with implications as an anticancer vaccine. CD83-IgG1(fc) chimera studies indicate that CD83 is a sialic acid-binding, Ig-like lectin (Siglec) adhesion molecule that is involved in cell adhesion/signaling by hosting dendritic cell interactions with monocytes and CD8+ T cells..

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CD83 (P130) polyclonal antibody detects endogenous levels of CD83 protein.

BiowMW :~ 23, 45 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :CD83 antigen; hCD83; B-cell activation protein; Cell surface protein HB15; CD83

Immunogen :Synthetic peptide, corresponding to amino acids 100-150 of Human CD83.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of CD83 (P130) polyclonal antibody at 1:500 dilution Lane1:Hela cell lysate Lane2:sp2/0 cell lysate Lane3:PC12 cell lysate

Immunohistochemistry (IHC) analyzes of CD83 (P130) pAb in paraffin-embedded human lung carcinoma tissue.

immature dendritic cells on the balance between pro-inflammatory and anti-inflammatory cytokines in DBA/1 mice with collagen-induced arthritis

JournalInflammation Research

ApplicationICC

IF3.061

SpeciesMouse

PMID24458308