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AK6 (G35) polyclonal antibody（KU）

货号: BS2171

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS2171

Product Name :AK6 (G35) polyclonal antibody（KU）

Swiss-Prot :Q9Y3D8

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IP: 1:10~1:100

Background :TAF9(AK6) functions as a component of the DNA-binding general transcription factor complex TFIID and the regulatory transcription complex SAGA. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. SAGA influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3 and SPT8) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3, and TRA1), and chromatin modification through histone acetylation (GCN5).

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :AK6 (G35) polyclonal antibody detects endogenous levels of AK6 protein.

BiowMW :~ 20 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Adenylate kinase isoenzyme 6; AK6; Adrenal gland protein AD-004; Coilin-interacting nuclear ATPase protein; hCINAP; Dual activity adenylate kinase/ATPase; AK/ATPase; CINAP; AD-004; CGI-137

Immunogen :Synthetic peptide, corresponding to the N-terminual of Human AK6.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of AK6 (G35) polyclonal antibody at 1:1000 dilution Lane1:A549 whole cell lysate(40ug) Lane2:The Lung tissue lysate of Rat(30ug) Lane3:The Lung tissue lysate of Mouse(30ug)

Immunoprecipitation of HEK293T cell lysate using AK6 (G35) polyclonal antibody (Sepharose Bead Conjugate) #BD0048(lane 2 and lane 3) and Nonspecific IgG Control (Sepharose Bead Conjugate) #BD0048 (lane 4 ).Lane 1 is 30% input.The western blot was probed using ATP5H (D146) #BS2171.“↑”（supernatant）;“↓(deposition）

Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation

JournalNature Communications

ApplicationWB

IF11.878

SpeciesHuman

PMID28516914