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CBX5 (K69) polyclonal antibody（KU）

货号: BS1999

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS1999

Product Name :CBX5 (K69) polyclonal antibody（KU）

Swiss-Prot :P45973

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :Heterochromatin protein 1 (HP1) is a family of heterochromatic adaptor molecules involved in both gene silencing and higher order chromatin structure. All three HP1 family members (α, β, and γ) are primarily associated with centromeric heterochromatin; however, HP1β and γ also localize to euchromatic sites in the genome. HP1 proteins are approximately 25 kDa in size and contain a conserved amino-terminal chromodomain, followed by a variable hinge region and a conserved carboxy-terminal chromoshadow domain. The chromodomain facilitates binding to histone H3 tri-methylated at Lys9, a histone "mark" closely associated with centromeric heterochromatin.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CBX5 (K69) polyclonal antibody detects endogenous levels of CBX5 protein.

BiowMW :~ 25 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Examples of Crosstalk Between Post-translational Modifications,DNA Methylation,

Alternative Name :Chromobox protein homolog 5; Antigen p25; Heterochromatin protein 1 homolog alpha; HP1 alpha; HP1α; CBX5; HP1A

Immunogen :Synthetic peptide, corresponding to amino acids 50-100 of Human CBX5.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of CBX5 (K69) pAb at 1:500 dilution Lane1:MEF whole cell lysate(40ug) Lane2:C6 whole cell lysate(40ug) Lane3:K562 whole cell lysate(40ug) Lane4:Hela whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of CBX5 (K69) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.