Product Name :CaSR (A884) polyclonal antibody
Reactivity :Human,Mouse,Rat
Application_all :IHC: 1:50~1:200
Background :The calcium sensing receptor (CaSR) has been shown to play
a major role in regulating parathyroid hormone secretion and
subsequently influencing the calcium concentration of extracellular
fluids. Based on sequence analysis of cDNA clones
it appears that the CaSR is similar to the 7-transmembranedomain
G-protein-coupled receptor superfamily. Changes in
extracellular calcium are thought to modulate a balance between
proliferation and differentiation in a variety of cell
types. In normal primary keratinocytes and breast epithelial
cells, proliferation is inhibited and elevated extracellular
calcium levels trigger differentiation. Malignant transformations
of these cell types are accompanied by a loss of responsiveness
to the anti-proliferative effects of elevated extracellular
calcium.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :CaSR (A884) polyclonal antibody detects endogenous levels of CaR protein.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :Extracellular calcium-sensing receptor; CaSR; Parathyroid cell calcium-sensing receptor 1; PCaR1; CASR; GPRC2A; PCAR1
Immunogen :Synthetic peptide, corresponding to amino acids 850-900 of Human CaSR.
Modification :Unmodification
