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AURKB (Y8) polyclonal antibody

货号: BS1722

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :BS1722

Product Name :AURKB (Y8) polyclonal antibody

Swiss-Prot :Q96GD4

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :Aurora kinases belong to a highly conserved family of mitotic serine/threonine kinases with three members identified among mammals: Aurora A, B, and C. Studies on the temporal expression pattern and subcellular localization of Aurora kinases in mitotic cells suggest an association with mitotic structure. Aurora kinase functional influences span from G2 phase to cytokinesis and may be involved in key cell cycle events such as centrosome duplication, chromosome bi-orientation and segregation, cleavage furrow positioning, and ingression.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :AURKB (Y8) polyclonal antibody detects endogenous levels of AURKB protein

BiowMW :~ 39 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Regulation of Microtubule Dynamics,

Alternative Name :Aurora kinase B; Aurora 1; Aurora- and IPL1-like midbody-associated protein 1; AIM-1; Aurora/IPL1-related kinase 2; ARK-2; Aurora-related kinase 2; STK-1; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase 5;Serine/threonine-protein kinase aurora-B; AURKB; AIK2; AIM1; AIRK2; ARK2; STK1; STK12; STK5

Immunogen :Synthetic peptide, corresponding to the N-terminal of Human AURKB.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of AURKB (Y8) polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate(40ug) Lane2:AML-12 whole cell lysate(40ug) Lane3:PC12 whole cell lysate(40ug) Lane4:Jurkat whole cell lysate(40ug) Lane5:THP-1 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of AURKB (Y8) pAb in paraffin-embedded liver cancer tissue at 1:100.

Let-7b regulates the adriamycin resistance of chronic myelogenous leukemia by targeting AURKB in K562/ADM cells

JournalLeukemia & Lymphoma

ApplicationWB

IF2.969

SpeciesHuman

PMID32856506