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CD31/PECAM-1 (T709) polyclonal antibody （KU）

货号: BS1574

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS1574

Product Name :CD31/PECAM-1 (T709) polyclonal antibody （KU）

Swiss-Prot :P16284

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :CD31 (Platelet Endothelial Cell Adhesion Molecule-1: PECAM-1), a member of the Ig superfamily of cell adhesion molecules, is expressed by circulating platelets, monocytes, neutrophils, some T cells and endothelial cells, and modulates cell adhesion, endothelial cell migration and angiogenesis. CD31 is phosphorylated on Tyr686 at the cytoplasmic carboxy-terminal tail upon various stimuli (e.g. mechanical stress or oxidative stress), presumably by Src family members. The tyrosine phosphorylation mediates associations with a number of SH2 domain containing binding partners such as PI3-kinase, SHIP, PLCγ and SHP-2. Thus, CD31 serves as a scaffold for various signaling molecules.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CD31/PECAM-1 (T709) polyclonal antibody detects endogenous levels of CD31 protein.

BiowMW :~ 140 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Platelet endothelial cell adhesion molecule; PECAM-1; EndoCAM; GPIIA'; PECA1; CD31; PECAM1

Immunogen :Synthetic peptide, corresponding to amino acids 670-720 of Human CD31.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of CD31/PECAM-1 (T709) pAb at 1:500 dilution Lane1:A549 whole cell lysate(30ug) Lane2:Raw264.7 whole cell lysate(40ug) Lane3:C6 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of CD31/PECAM-1 (T709) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

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