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Lamin A/C (R386) polyclonal antibody（KU）

货号: BS1446

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS1446

Product Name :Lamin A/C (R386) polyclonal antibody（KU）

Swiss-Prot :P02545

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :A unique family of cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, termed CED-3/ICE, functions as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Nuclear lamins are critical to maintaining the integrity of the nuclear envelope and cellular morphology.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Lamin A/C (R386) polyclonal antibody detects endogenous levels of Lamin A/C protein.

BiowMW :~ 74, 65 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Prelamin-A/C; Lamin-A/C; Lamin A/C; LaminA/C; 70 kDa lamin; Renal carcinoma antigen NY-REN-32; LMNA; LMN1; Lamin A; LaminA; Lamin-A; Lamin C; LaminC; Lamin-C

Immunogen :Synthetic peptide, corresponding to amino acids 351-400 of Human Lamin A/C.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Lamin A/C (R386) polyclonal antibody at 1:500 dilution Lane1:HepG2 whole cell lysate(40ug) Lane2:L02 whole cell lysate(40ug) Lane3:PC12 whole cell lysate(40ug) Lane4:AML-12 whole cell lysate(40ug) Lane5:A549 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of Lamin A/C (R386) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

MLN4924 suppresses tumor metabolism and growth of clear cell renal cell carcinoma by stabilizing nuclear FBP1

JournalCell Death Discovery

ApplicationWB

IF6.1

SpeciesHuman

PMID40419474