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GYS (P539) polyclonal antibody（KU）

货号: BS1151

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS1151

Product Name :GYS (P539) polyclonal antibody（KU）

Swiss-Prot :P13807

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Glycogen is a polysaccharide of glucose and serves as an energy storage in mammalian muscle and liver. Glycogen synthase catalyzes the rate-limiting step of glycogen biosynthesis and has two major isoforms in mammals -- muscle isoform (GYS1) and liver isoform (GYS2) respectively. Glycogen synthase kinase-3α (GSK-3α) and glycogen synthase kinase-3β (GSK-3β) phosphorylate glycogen synthase at multiple sites in its C-terminus (Ser641, Ser645, Ser649 and Ser653) inhibiting its activity. Hypoxia alters glycogen metabolism including temporal changes of GYS1 expression and phosphorylation in cancer cells, suggesting the role of metabolic reprogramming of glycogen metabolism in cancer growth.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :GYS (P539) polyclonal antibody detects endogenous levels of GYS protein.

BiowMW :~ 84 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Regulation of Actin Dynamics,Insulin &Glucose Signaling,

Alternative Name :Glycogen [starch] synthase, muscle; GYS1; GYS

Immunogen :Synthetic peptide, corresponding to Human GYS.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of GYS (P539) polyclonal antibody at 1:500 dilution Lane1:H1792 whole cell lysate(40ug) Lane2:LO2 whole cell lysate(40ug) Lane3:HEK293T whole cell lysate(40ug)

Human Mesenchymal Stem Cell Derived Exosomes Alleviate Type 2 Diabetes Mellitus by Reversing Peripheral Insulin Resistance and Relieving β-Cell Destruction

JournalACS Nano

ApplicationWB

IF13.903

SpeciesRat

PMID30052036
Long-term kappa-carrageenan consumption leads to moderate metabolic disorder by blocking insulin binding

JournalPharmacological Research

ApplicationWB

IF5.893

SpeciesHuman, Mouse

PMID